Chemistry reference ranges are often unavailable for local populations participating in international clinical trials. This paper identifies a simple approach to defining normal hepatic and biochemistry ranges among clinical trial participants. Embedding the process early in the screening phase of a clinical trial is cost-effective and may reveal population differences that are important in classifying toxicities that occur during the trial.
Verification of chemistry reference ranges using a simple method in sub-Saharan Africa
Written By
De Baetselier I, Taylor D, Mandala J, Nanda K, Van Campenhout C, Agingu W, Madura L, Barsch EM, Deese J, Van Damme L, Crucitti T