This analysis of early mucosal infections in women revealed high HIV-1 viral diversity in the vaginal tract but few transmitted clones in the blood. This provides novel in vivo evidence for a mucosal sieve effect, leading to the establishment of a homogenous systemic infection. The data will have significant implications in rational vaccine design.
Higher sequence diversity in the vaginal tract than in blood at early HIV-1 infection
Written By
Klein K, Nickel G, Nankya I, Kyeyune F, Demers K, Ndashimye E, Kwok C, Chen PL, Rwambuya S, Poon A, Munjoma M, Chipato T, Byamugisha J, Mugyenyi P, Salata RA, Morrison CS, Arts EJ
