The authors compared the efficacy and safety of antiretroviral (ART) strategies for the prevention of mother-to-child transmission among asymptomatic HIV-infected pregnant women with high CD4 counts. Triple-drug ART resulted in significantly lower rates of early HIV transmission than zidovudine alone but resulted in a higher risk of adverse outcomes. These findings emphasize the need for continued research to assess ART in pregnancy.
Benefits and risks of antiretroviral therapy for perinatal HIV prevention
Written By
Fowler MG, Qin M, Fiscus SA, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti AS, Taha TE, Klingman KL, Martinson FE, Owor M, Violari A, Moodley D, Theron GB, Bhosale R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AJ, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM, IMPAACT 1077BF/1077FF PROMISE study team
