Randomized trial of periodic presumptive treatment with high-dose intravaginal metronidazole and miconazole to prevent vaginal infections in HIV-negative women

This study tested the efficacy of a novel regimen to prevent recurrent vaginal infections. Monthly treatment with intravaginal metronidazole plus miconazole reduced the proportion of visits with bacterial vaginosis during 12 months of follow-up. Further study will be important to determine whether this intervention can reduce women’s risk of sexually transmitted infections.