Genomic analysis has become one of the major tools for disease outbreak investigations. This paper proposes a Quasispecies Evolution, Network-based Transmission Inference (QUENTIN) framework for conducting genomic analyses of outbreaks of highly mutable viruses associated with chronic infections, such as HIV and hepatitis C virus. The QUENTIN framework uses relevant properties of social networks to address previously identified shortcomings of existing computational frameworks for inference of transmission history from viral genomic data.
QUENTIN: Reconstruction of disease transmissions from viral quasispecies genomic data
Written By
Skums P, Zelikovsky A, Singh R, Gussler W, Dimitrova Z, Knyazev S, Mandric I, Ramachandran S, Campo D, Jha D, Bunimovich L, Costenbader E, Sexton C, O’Connor S, Xia GL, Khudyakov Y
