Home | Published Research | Pharmacokinetics of dapivirine transfer into blood plasma, breast milk, and cervicovaginal fluid of lactating women using dapivirine vaginal ring

January 1, 2019

Pharmacokinetics of dapivirine transfer into blood plasma, breast milk, and cervicovaginal fluid of lactating women using dapivirine vaginal ring

Written By

Noguchi LM, Hoesley C, Kelly C, Scheckter R, Bunge K, Nel A, Marzinke MA, Hendrix CW, Dezzutti CS, Hillier SL, Bogen DL, Piper JM, Beigi RH

This study assessed the pharmacokinetics, safety, tolerability and adherence of the dapivirine vaginal ring used for 14 consecutive days by lactating women who were not breastfeeding. The research showed low concentrations of dapivirine in breast milk, indicating that daily infant exposure would also be low. Given this favorable safety profile, additional research is in development to assess the safety and drug detection of the dapivirine ring in breastfeeding mother-infant pairs in regions with higher incidence of sexually transmitted HIV infection.