Given that topical microbicides can achieve high drug concentrations in mucosal tissue, it was imperative to further assess changes that occur at the molecular level should tenofovir 1% gel become used for HIV prevention. This exploration into the potential adverse effects and various mucosal changes induced by tenofovir 1% gel, when used for seven days, highlighted concerns regarding its safety over long-term use.
Mucosal effects of tenofovir 1% gel
Written By
Hladik F, Burgener A, Ballweber L, Gottardo R, Vojtech L, Fourati S, Dai JY, Cameron MJ, Strobl J, Hughes SM, Hoesley C, Andrew P, Johnson S, Piper J, Friend DR, Ball TB, Cranston RD, Mayer KH, McElrath MJ, McGowan I.
