Implementation of 350-2500 nm diffuse reflectance spectroscopy and high-performance thin-layer chromatography to rapidly assess manufacturing consistency and quality of cotrimoxazole tablets in Tanzania

In a resource-limited environment, a newly instituted rapid assessment quality assurance program was used to assess the quality of cotrimoxazole tablets. This cost-effective approach provides a model to assure product quality and make significant improvements to the continual product quality from the manufacturer. With proper validation, this approach could be applied in other countries and on other product formulations.