These data indicate that sex affects tenofovir gel pharmacokinetics and has implications for other microbicides and delivery methods. As research on microbicide gels, rings and other delivery platforms move forward, it will be important to conduct post-coital pharmacokinetics studies to optimize the timing and dosing of the prevention agent.
Impact of sex on the pharmacokinetics and pharmacodynamics of 1% tenofovir gel
Written By
Herold BC, Chen BA, Salata RA, Marzinke MA, Kelly CW, Dezzutti CS, McGowan I, Galaska B, Levy L, Piper JM, Hillier S, Hendrix CW, MTN-011 study team.
