Factors associated with non-completion of follow-up: 33-month latent tuberculous infection treatment trial

Valid clinical trials rely on patients to adhere to treatments and to participate until the end of the study. This secondary analysis of a published tuberculosis prevention study showed that patients at a higher risk of not completing the study were identified by characteristics known at enrollment or shortly thereafter. These findings can help future studies minimize attrition by, for example, restricting the proportion enrolled with high-risk characteristics or increasing sample sizes.