Drug interactions between hormonal contraceptives and antiretrovirals

This review of published literature summarizes studies of women using hormonal contraceptives and antiretrovirals concurrently. The authors found pharmacokinetic data suggesting that certain antiretrovirals may reduce concentrations of contraceptive hormones with certain methods. Although pregnancy rates are slightly increased, particularly for implants, they remain very effective despite these interactions. Women taking antiretrovirals for treatment or prevention should not be denied access to the full range of hormonal contraceptive options.