The authors measured 10 biomarkers of cervical inflammation and immunity and compared biomarker levels longitudinally across HIV status, contraceptive and pregnancy groups. The authors found differing longitudinal patterns of cervical immunity, rates of regulated upon activation normal T cell expressed and secreted (RANTES) and levels of secretory leukocyte protease inhibitor (SLPI) across the groups. The results suggest that RANTES may be associated both with HIV acquisition risk and depot medroxyprogesterone acetate (DMPA) use.
A longitudinal assessment of cervical inflammation and immunity associated with HIV-1 infection, hormonal contraception and pregnancy
Written By
Morrison C, Fichorova R, Chen PL, Kwok C, Deese J, Yamamoto H, Anderson S, Chipata T, Salata R, Doncel G
