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7 Results Found

  • Published research

    A tale of two parasites: Statistical modelling to support disease control programmes in Africa

  • Published research

    Size estimation of key populations in the HIV epidemic in eSwatini using incomplete and misaligned capture-recapture data

  • Published research

    QUENTIN: Reconstruction of disease transmissions from viral quasispecies genomic data

    Genomic analysis has become one of the major tools for disease outbreak investigations. This paper proposes a Quasispecies Evolution, Network-based Transmission Inference (QUENTIN) framework for conducting genomic analyses of outbreaks of highly mutable viruses associated with chronic infections, such as HIV and hepatitis C virus. The QUENTIN framework uses relevant properties of social networks to address previously identified shortcomings of existing computational frameworks for inference of transmission history from viral genomic data.
  • Published research

    Real-time monitoring through the use of technology to enhance performances throughout HIV cascades

    The authors found numerous publications documenting uses of technology at various stages of the HIV prevention-to-treatment cascade. But, they noted a lack of evidence on technology to track and improve services across the entire cascade. This review highlights lessons learned from a range of technical solutions for HIV services. The paper will inform successful real-time program monitoring.
  • Published research

    Attitudes and perceptions toward novel objective measures of ARV-based vaginal ring use: Results from a global stakeholder survey

    The authors conducted a survey of stakeholders with experience and expertise in microbicide and HIV prevention clinical trials. They found that methods that require no additional input from the participant and no modifications to the existing ring product are viewed as more acceptable to trial participants and more feasible to implement in the field.
  • Published research

    CONSORT statement for randomized trials of nonpharmacologic treatments: A 2017 update and a CONSORT extension for nonpharmacologic trial abstracts

    This article describes a Consolidated Standards of Reporting Trials (CONSORT) extension to the CONSORT 2010 Statement that addresses methodological issues specific to trials of nonpharmacologic treatments, such as surgery, rehabilitation or psychotherapy. To develop these materials, the authors reviewed published literature, surveyed authors and conducted a consensus meeting. This update should enable researchers who are writing journal articles to increase the transparency of their reports and the accuracy of trial result interpretations.
  • Published research

    Evidence-based strategies for shortening informed consent forms in clinical research

    Long informed consent forms can negatively affect potential participants’ understanding of clinical research. The authors present three strategies for reducing form length that were developed by consensus among six groups of key stakeholders. Implementing these strategies will facilitate adoption of the proposed changes to U.S. regulations on form length, to make the consent process more useful for participants.