Mario Chen, PhD, MS

Associate Director, Biostatistics

Areas of expertise

  • Biostatistics
  • Quantitative analysis
  • Clinical research
  • Epidemiology
  • Evaluation
  • Training
  • Data monitoring

Projects & Resources

  • Linking Communities and Scientists to Durham HIV Prevention (LinCS 2 Durham) is a community-based participatory research project that brings members of the Black community in Durham, NC, and scientists together to help chart the course of future HIV prevention research in the city.

  • The International Clinical Studies Support Center (ICSSC) at FHI 360 provides a wide range of support services to clinical investigators conducting international research on treatment, prevention and control of infectious diseases in developing countries.

Published Research

  • Factors associated with HIV RNA viral loads in ART-naïve patients: Implications for treatment as prevention in concentrated epidemics
    Rangarajan S, Colby DJ, Truong GL, Huu HN, Thu VT, Quoc BL, Broh TP, Tri DT, Giang DD, Chen M, Zeng Y, West G
    J Virus Erad 2016 Jan; 2(1): 36-42. [Journal Impact Factor: n/a]

    The authors conducted a survey of adults with HIV who are not on antiretroviral treatment (ART) in Ho Chi Minh City, Vietnam. These data support expanded eligibility of ART to all HIV patients with the goal of treatment as prevention. This study is among the first to demonstrate that men who have sex with men have a higher viral load than women and heterosexual men. This highlights the need for improved outreach and linkages to HIV care for this population.

  • Factors associated with HIV viral load suppression on antiretroviral therapy in Vietnam
    Rangarajan S, Colby DJ, Truong GL, Duong BD, Huu HN, Broh TP, Tri DT, Chau TN, Anh ND, Tram HN, Nga DV, Quang NN, Phuoc PV, Giang DD, Chen M, Zeng Y, Van TT, Hanh TM, Hoa LT, Chien HX, West G
    J Virus Erad 2016 Apr; 2(2): 94-101. [Journal Impact Factor: n/a]

    The authors conducted a survey of adult patients, across four provinces in Vietnam, who have been on antiretroviral treatment (ART) for at least one year. The survey assessed the effectiveness of the national HIV treatment program and showed that the program can maintain and potentially improve treatment outcomes by improving access to viral load testing, including a routine test for all patients following one year on ART, streamlining adherence monitoring and counseling, proactively switching patients to the available single-tablet regimen, and mobilizing interventions to address issues of social isolation and high stigma among people living with HIV.

  • Evaluating bang for the buck: A cost-effectiveness comparison between individual interviews and focus groups based on thematic saturation levels
    Namey E, Guest G, McKenna K, Chen M
    Am J Eval 2016 Sep; 37(3): 425-40. [Journal Impact Factor: 0.808]

    Individual interviews and focus group discussions form the foundation of most qualitative research and evaluation activities. The authors provide an empirical comparison of cost and time required to reach data saturation using the two methods, based on actual expenditures from parallel interview and focus group datasets generated through random allocation of participants. Interviews were more cost-effective in most contexts.

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