Elizabeth Tolley, PhDScientist, Social and Behavioral Health Sciences
Areas of expertise
- HIV prevention research
- HIV in adolescents
Projects & Resources
Should ongoing clinical trials identify an effective microbicide, the next challenge will be to ensure product access and use. Communication campaigns will play a critical role in generating demand and encouraging correct use.
FHI 360 developed and introduced innovative HIV prevention technologies — including microbicides and antiretrovirals — and worked with local partners to address the need for HIV prevention options, particularly for women.
Published Research/** * @file * Unformatted override for published research. * Using the same markup as "project" because it's the same */ ?>
Biomarkers and biometric measures of adherence to use of ARV-based vaginal rings
Stalter RM, Moench TR, MacQueen KM, Tolley EE, Owen DH, Consortium for Ring Adherence
J Int AIDS Soc 2016 May; 19 (1): 20746. [Journal Impact Factor: 5.090]
Poor adherence has been observed in trials of HIV prevention products containing antiretroviral-based oral and vaginal gel, resulting in an inability to determine product efficacy. This landscape analysis was conducted to identify potential technologies for objective product adherence measurement in antiretroviral-based HIV prevention trials to accurately determine efficacy. The authors recommend a strategy of using complementary biometric and behavioral approaches to best understand participants' adherence to antiretroviral-based vaginal rings in clinical trials.
School-based interventions for improving contraceptive use in adolescents (review)
Lopez LM, Bernholc A, Chen M, Tolley EE
Cochrane Database Syst Rev 2016 Jun; (6): CD012249, 74p. [Journal Impact Factor: 6.103]
This paper is a systematic review of randomized controlled trials of school-based interventions intended to improve contraceptive use among adolescents. The authors found that effective interventions addressed both pregnancy and prevention of HIV and sexually transmitted infections and that successful strategies were generally multifaceted with multiple sessions. These findings suggest that interactive programs with varied activities are more likely than a didactic approach to engage adolescents and lead to behavior change.
Socioeconomic and behavioral factors influencing choice, adherence and success of microbicide formulations
Tolley E, Friedland B, Gafos M, Amico R, Van Damme L, Woodsong C, MacQueen K, Mansoor L, McCormack S
In: das Neves, Jose, Sarmento, Bruno, editors. Drug delivery and development of anti-HIV microbicides. Singapore: Pan Stanford Publishing; 2015. pp. 569-654. [Journal Impact Factor: n/a]
High product adherence is critical to the success of HIV prevention trials and the public health impact of products available in clinics. Some adherence determinants in these two contexts differ. This chapter presents a conceptual framework and draws widely on published and unpublished data to discuss the socioeconomic and behavioral factors influencing choice, adherence and success of different microbicide formulations.